All My Children — ABC soap opera set in fictional Pine Valley on Philadelphia's Main Line.
American Bandstand — ABC music show in Philadelphia and later in Los Angeles
American Dreams — NBC family drama set in Philadelphia
Amish Mafia — Discovery reality show set in Lancaster
Back to You — Fox comedy set in Pittsburgh
Banshee — Cinemax crime drama set in Banshee (fictional)
Big Lake — Comedy Central comedy set in Big Lake (fictional)
Body of Proof — ABC crime drama set in Philadelphia
Cold Case — CBS crime drama set in Philadelphia
Dance Moms — Lifetime reality show set in Pittsburgh
The Devide — WEtv drama set in Philadelphia
Do No Harm — NBC medical drama set in Philadelphia
Flesh and Bone — Starz drama set in New York City. The main character is from Pittsburgh, Pennsylvania.
The Fresh Prince of Bel-Air — NBC comedy set in Bel-Air. The main character was from Philadelphia, Pennsylvania.
The Guardian — CBS legal drama set in Philadelphia
Hack — CBS crime drama set in Philadelphia
Heartland — TNT medical drama set in Pittsburgh
Hemlock Grove — Netflix vampire drama set in Hemlock Grove (fictional)
House of Cards — Netflix political drama set in DC, with the main congressional character being from South Carolina, and a secondary congressional character from Pennsylvania.
It's Always Sunny in Philadelphia — FX comedy set in Philadelphia
Jon & Kate Plus 8 — TLC reality show set in Wernersville
The Kill Point — Spike crime drama set in Pittsburgh
Longmire — A&E crime drama set in Absaroka County and Durand, Nebraska. One of the main characters was originally from Philadelphia, Pennsylvania. The series is filmed around Santa Fe, New Mexico.
Monica the Medium — ABC Family reality show set in College Station, Pennsylvania
Mr. Rogers Neighborhood — PBS children's show set in Pittsburgh
Nightwatch Pittsburgh — A&E reality show set Pittsburgh
The Office — NBC comedy set in Scranton
One Life to Live — ABC daytime soap opera set in Llanview (fictional)
Paranormal State — A&E series about Penn State University students looking for ghosts
Parking Wars — A&E reality show set in Philadelphia
Philly — ABC legal drama set in Philadelphia
Philly Undercover — National Geographic Wild reality show set in Philadelphia
Pretty Little Liars — ABC Family drama set in Rosewood (fictional) and Delaware County (real place)
Queer As Folk — Showtime drama set in Pittsburgh
Ravenswood — ABC Family drama set in Rosewood (fictional) and Delaware County (real place)
The Real World: Philadelphia — MTV reality show set in Philadelphia
Romantically Challenged — ABC comedy set in Pittsburgh
Star — Fox music soap opera set in Atlanta, Georgia with the principle
characters originally from Pittsburgh, Pennsylvania.
Sullivan & Son — TBS drama set in Pittsburgh. The main character was previously a Wall Street investment banker.
Teach: Tony Danza — A&E reality show set in Philadelphia
thirtysomething — ABC drama set in Philadelphia
This Is Us — NBC comedy set in Pittsburgh
'Til Death — Fox comedy set in Philadelphia